Highway 281 & Encino Rio
San Antonio, TX 78258 Encino

This upcoming Class A medical office building offers a rare pre-leasing opportunity in one of San Antonio’s most dynamic growth corridors. Located at the highly visible intersection of U.S. Highway 281 and Encino Rio, the two-story facility is designed with modern healthcare users in mind, providing efficient layouts and excellent ingress and egress for both patients and staff.
The property will feature a contemporary design, ample natural light, and convenient access to major transportation routes, including Loop 1604 and U.S. Highway 281. With a parking ratio of 5.5 spaces per 1,000 SF, the site ensures ease of access for visitors and employees. Additional contiguous land is available for build-to-suit opportunities, and ownership offers a limited partnership investment option for qualified tenants.
Situated within a thriving trade area, the location benefits from strong population growth, high household incomes, and proximity to major retail, dining, and healthcare facilities. This makes it an exceptional choice for medical professionals seeking to establish or expand their presence in a high-demand market.

• Date available: Jan 2028
• Lease term: Negotiable
• Service type: Triple Net
• Space Type: New

This upcoming Class A medical office building offers a rare pre-leasing opportunity in one of San Antonio’s most dynamic growth corridors. Located at the highly visible intersection of U.S. Highway 281 and Encino Rio, the two-story facility is designed with modern healthcare users in mind, providing efficient layouts and excellent ingress and egress for both patients and staff.
The property will feature a contemporary design, ample natural light, and convenient access to major transportation routes, including Loop 1604 and U.S. Highway 281. With a parking ratio of 5.5 spaces per 1,000 SF, the site ensures ease of access for visitors and employees. Additional contiguous land is available for build-to-suit opportunities, and ownership offers a limited partnership investment option for qualified tenants.
Situated within a thriving trade area, the location benefits from strong population growth, high household incomes, and proximity to major retail, dining, and healthcare facilities. This makes it an exceptional choice for medical professionals seeking to establish or expand their presence in a high-demand market.

• Date available: Jan 2028
• Lease term: Negotiable
• Service type: Triple Net
• Space Type: New