List Search

601-621 Portola Dr
San Francisco, CA 94127 Miraloma

$4,998 - $8,520 USD/MO

Office Residential For Lease  •  840+ SF

Property Details

  • Property Type Office Residential
  • Year Built 1990
  • Total Building Size 5,353 SF
  • Tenancy Multiple
  • Building Class B
  • Zoning NC-1
90 Transit Score
70 Walk Score

2 Spaces Available

Name Space Use Size Rent Details
Grnd Floor Ste 601 Medical Office 3,000 SF $34.08 USD/SF/YR
  • Date available: Now
  • Lease term: Negotiable
  • Service type: Triple Net
  • Space Type: Relet
1st Floor Ste 621 Office/Retail 840 SF $71.40 USD/SF/YR
Excellent Corner Location – 621 Portola Drive

In retail, location determines momentum—and 621 Portola Drive delivers a powerful one.

Positioned prominently at the corner of Portola Drive and Teresita Boulevard in San Francisco’s desirable Twin Peaks neighborhood, this highly visible storefront benefits from steady neighborhood traffic, strong street presence, and built-in community engagement. The intersection placement provides exceptional signage exposure and natural walk-by activity—critical advantages for neighborhood-serving businesses.

Zoned NC-1 (Neighborhood Commercial – Cluster One), the property supports a range of community-focused uses, including cafés, boutiques, specialty retail, personal services, wellness concepts, and professional offices. This zoning encourages businesses that become part of the neighborhood fabric—establishments that generate repeat clientele and long-term loyalty.

A Built-In Customer Base

Twin Peaks is known for its tree-lined streets, established residential density, and strong sense of community. The surrounding homes create a consistent local customer base within walking distance—an invaluable driver for retail success.

The property is also strategically located near West Portal and Glen Park, expanding the trade area and increasing daily consumer flow. Easy access to MUNI lines and major thoroughfares ensures convenience for both neighborhood residents and visitors.

Directly adjacent is Mollie Stone’s Markets, a well-established specialty grocer that anchors the corridor and drives consistent foot traffic. Nearby dining destinations such as Fresca and Mozzarella di Bufala further enhance the vibrancy of the immediate area, creating a synergistic retail environment.

Property Highlights

840 sq. ft. vacant corner unit

High-visibility frontage at a signalized intersection

NC-1 zoning supporting neighborhood-serving retail and service uses

Flexible open layout — ideal blank canvas for customization

Private restroom

Strong pedestrian and vehicle exposure

Adjacent to an established grocery anchor

Located within a stable, high-demand residential community

Why This Location Works

Corner positioning enhances brand recognition.

Consistent daily neighborhood traffic

Established residential density supports repeat customers

Proximity to multiple vibrant commercial districts

Transit accessibility expands customer reach

621 Portola Drive offers more than space—it offers positioning. For businesses seeking strong community integration, consistent visibility, and long-term stability, this location provides a strategic foundation for success.

Contact us today to explore how your business can thrive at this exceptional Twin Peaks address.

  • Date available: Now
  • Lease term: Negotiable
  • Service type: Modified Gross
  • Built out as: Standard Retail
  • Space Type: Relet

Description

Prime Professional Medical/Wellness Office Space for Lease!!


Position your business for long-term success in this fully built-out, highly visible professional space located in a prime, high-traffic corridor. Formerly home to a thriving dental practice for over 27 years, this well-designed and versatile property offers an exceptional opportunity for dental, medical, wellness, or select retail users seeking a turnkey or easily adaptable environment.

Whether you are launching, expanding, or relocating, this space provides the infrastructure, visibility, and flexibility to support your growth—without the time and expense of building from the ground up.

Property Features:

Generous Layout:
Approximately 3,000 sq. ft. of thoughtfully designed, functional space suitable for clinical, professional, or boutique commercial use.

Built-Out Clinical Infrastructure
Eight fully equipped operatories with plumbing, cabinetry, and fixtures already in place—ideal for dental use and readily adaptable for medical, wellness, or treatment-based services.

Welcoming Reception Area:
Spacious and comfortable waiting environment designed to enhance client and patient experience.

Private Offices & Staff Areas:
Dedicated administrative and provider offices, plus staff workspace and full kitchen/breakroom to support daily operations efficiently.

Specialized Equipment & Treatment Areas:
Includes digital X-ray system, sterilization room, and darkroom—convertible for medical imaging, lab, or procedural use depending on tenant needs.

Restrooms:
Modern, clean, and well-maintained facilities for patients, clients, and staff.

Ample On-Site Parking:
Convenient parking for both staff and visitors—an essential feature for healthcare and customer-facing businesses.

Move-In Ready:
Existing improvements allow for immediate occupancy, with flexibility for customization.

Location Advantages:

High-Visibility Setting:
Prominent location with strong vehicle and foot traffic, providing excellent exposure for healthcare or retail-oriented businesses.

Excellent Accessibility:
Conveniently located near major transportation routes, residential neighborhoods, and established commercial services.

Strong Community Demographics:
Situated in a well-established area with consistent demand for healthcare, wellness, and neighborhood-serving retail services.

Lease Highlights:

Flexible Lease Terms
Structured to accommodate a range of professional, medical, or retail users.

Tenant Improvement Opportunities:
Ability to customize layout and finishes to suit dental, medical, wellness, or boutique retail concepts.

Immediate Occupancy Available:
Minimal downtime—ideal for businesses seeking a seamless transition.

Ideal Uses:

This versatile space is well-suited for:

Dental Practice (General or Specialty)

Medical or Healthcare Office

Wellness / Aesthetic / MedSpa

Physical Therapy or Rehabilitation

Specialty Medical Services

Professional Office Use

Boutique Health-Focused or Service Retail (subject to approval)

Building Highlights

Prime high-visibility location with strong exposure

Former long-standing dental practice (27+ years)

Turnkey clinical infrastructure with existing plumbing and wiring

Flexible layout adaptable for medical, dental, wellness, or retail use

Professional reception, private offices, and staff facilities

On-site parking for convenience and accessibility

Close proximity to major transportation corridors

Zoning supports medical, professional, and related commercial uses

Located in an established, high-demand service area

Opportunity:

This is a rare opportunity to secure a well-located, fully improved professional space with exceptional flexibility. Whether continuing as a dental office or transforming into a medical, wellness, or specialty retail destination, the foundation is already in place for long-term success.

Contact us today to schedule a private tour and explore how this space can support your next phase of growth.

Highlights

Heavy Traffic Corner in Twin Peaks-Established Dental office of 27 years.

Amenities

  • Bus Line

Major Tenants

Tenant SF Occupied Lease End Date
Caken' Cuts Barbershop
Portola Nail Spa
Pro Dental Care
Tower Cleaners

Public Transportation

Commuter RailDriveWalkDistance
Bayshore Caltrain Station Southbound (Local Weekday - Caltrain (Caltrain), Local Weekend - Caltrain (Caltrain)) 10 min - 5.4 mi
San Francisco Caltrain Station Southbound (Express - Caltrain (Caltrain), Limited - Caltrain (Caltrain), Local Weekday - Caltrain (Caltrain), Local Weekend - Caltrain (Caltrain)) 11 min - 7.2 mi
Transit/SubwayDriveWalkDistance
Forest Hill (K Ingleside - San Francisco Municipal Railway (MUNI Metro), L Taraval - San Francisco Municipal Railway (MUNI Metro), M Ocean View - San Francisco Municipal Railway (MUNI Metro), T Third Street - San Francisco Municipal Railway (MUNI Metro)) 1 min 10 min 0.5 mi
Ulloa St & Lenox Way (OCEAN VIEW - San Francisco Municipal Transportation Agency, TARAVAL - San Francisco Municipal Transportation Agency) 3 min 18 min 1.0 mi
West Portal Station (INGLESIDE - San Francisco Municipal Transportation Agency, OCEAN VIEW - San Francisco Municipal Transportation Agency, TARAVAL - San Francisco Municipal Transportation Agency) 3 min 19 min 1.0 mi
AirportDriveWalkDistance
San Francisco International 21 min - 13.2 mi
Metro Oakland International 39 min - 23.4 mi

Parking Details

Parking Available: Yes
Reserved: No
Spaces Provided: 25
Type: Surface
Included in Rent: Yes
Jules Clark 415-938-8838 Clark and Crooner Real Estate Group
Jules Clark 415-938-8838 Clark and Crooner Real Estate Group