4240 Duncan Ave
Saint Louis, MO 63110 Central West End

Class A café space available in the heart of St. Louis’ Cortex Innovation District, the region’s leading hub for technology, research, and entrepreneurship. This beautifully designed 1,698 SF space is ideal for a coffee shop, bakery, or quick-service café seeking a prominent, walkable location in a neighborhood surrounded by thousands of daily professionals and students.
Enjoy a modern open layout, high ceilings, large windows, and natural light that creates a warm and inviting atmosphere. Outdoor seating and signage opportunities further enhance exposure and curb appeal.
Located in the Cortex Innovation District, this property sits within a 200-acre, 42-building community featuring 54 companies and over 5,700 employees. Nearby tenants include BJC Healthcare, Washington University School of Medicine, Vir Biotechnology, and AB Mauri Foods.
The site offers easy access to Forest Park Avenue, I-64, Brickline Greenway, and the MetroLink Station, ensuring strong pedestrian traffic and convenient connectivity to downtown St. Louis and the Central West End.

• Date available: Mar 2026
• Lease term: 3 - 5 Years
• Service type: Modified Gross
• Space Type: Relet