4220 Duncan Ave
Saint Louis, MO 63110 Central West End

Nestled in the heart of St. Louis’ thriving Cortex Innovation Community, 4220 Duncan Avenue presents a rare opportunity to lease a fully built-out 5,263-square-foot restaurant space, complete with two expansive outdoor patios totaling 2,126 square feet and a 394-square-foot cafe. This turnkey space is primed for immediate occupancy and tailored for high-volume food and beverage operations. Designed with exceptional interior finishes and excellent condition throughout, this space offers operators a ready-made platform to serve one of the Midwest's most vibrant business and tech ecosystems. With on-site anchor tenants such as Microsoft, Boeing, Accenture, and the Cambridge Innovation Center, 4220 Duncan Avenue delivers a steady flow of professionals and innovators looking for premium dining experiences.
  
Positioned off Interstate 64 and mere steps from the Cortex MetroLink Station, 4220 Duncan Avenue offers excellent connectivity to key destinations, including Downtown St. Louis, the airport, and surrounding districts. This highly walkable and well-connected location places it at the nexus of business, transit, and culture. Within a 3-mile radius, the area is home to 146,000 residents, 41% of whom hold a bachelor’s degree or higher, creating a strong, educated local demographic with purchasing power. Furthermore, over 141,000 daytime employees commute into the area daily, contributing to a steady demand for dining and catering opportunities. Within minutes, visitors can reach Downtown St. Louis, where entertainment, culture, and tourism converge at the Gateway Arch, Busch Stadium, and various event venues. 
   
As one of the region’s most transformative and fastest-growing districts, the Cortex Innovation Community delivers a distinct blend of technology, education, and urban energy. Surrounded by world-class institutions, healthcare facilities, and research centers, the neighborhood fosters a unique culture of creativity and collaboration. The strategic advantages of the building, the strength of the location, and the density of nearby talent and traffic make 4220 Duncan Avenue a high-impact choice for restaurant operators ready to grow within a forward-looking, opportunity-rich market.