4126 Southwest Fwy
Houston, TX 77027 Afton Oaks

Rate Upon Request

Medical For Lease • 955+ SF

Property Details

Property Type Medical
Year Built 1979
Total Building Size 142,430 SF
Tenancy Multiple
Building Class A

40 Transit Score

60 Walk Score

21 Spaces Available

Name	Space Use	Size	Rent
3rd Floor Ste 310	Medical Office	1,598 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 13,715 SF
3rd Floor Ste 330	Medical Office	3,330 SF	Rate Upon Request
Spacious office/Medical suite with 3,453 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 13,715 SF
4th Floor Ste 400	Medical Office	8,787 SF	Rate Upon Request
Spacious office/Medical suite with 9,111 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Space Type: Relet In Contiguous block: 13,715 SF
6th Floor Ste 610	Medical Office	1,697 SF	Rate Upon Request
Spacious office/Medical suite with 1,766 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 32,226 SF
7th Floor Ste 700	Medical Office	3,502 SF	Rate Upon Request
Spacious office/Medical suite with 3,741 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 32,226 SF
7th Floor Ste 710	Medical Office	3,616 SF	Rate Upon Request
Spacious office/Medical suite with 3,353 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Medical Space Type: Relet In Contiguous block: 32,226 SF
7th Floor Ste 730	Medical Office	955 SF	Rate Upon Request
Spacious office/Medical suite with 900 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Medical Space Type: Relet In Contiguous block: 32,226 SF
8th Floor Ste 800	Medical Office	4,641 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 32,226 SF
8th Floor Ste 820	Medical Office	3,590 SF	Rate Upon Request
Excellent building lobby exposure, ready for space planning. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Medical Space Type: Relet In Contiguous block: 32,226 SF
9th Floor Ste 999	Medical Office	9,085 SF	Rate Upon Request
Date available: 30 Days Lease term: 1 - 10 Years Service type: Triple Net Space Type: Relet In Contiguous block: 32,226 SF
10th Floor Ste 1030	Medical Office	2,153 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Space Type: Relet In Contiguous block: 32,226 SF
10th Floor Ste 1040	Medical Office	2,987 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Space Type: Relet In Contiguous block: 32,226 SF
12nd Floor Ste 1210	Medical Office	2,119 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Space Type: Relet In Contiguous block: 44,492 SF
12nd Floor Ste 1230	Medical Office	1,836 SF	Rate Upon Request
Spacious office/Medical suite with 1,941 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF
13rd Floor Ste 1300	Medical Office	8,227 SF	Rate Upon Request
Date available: 90 Days Lease term: 1 - 10 Years Service type: Negotiable Built out as: Standard Medical Space Type: Relet In Contiguous block: 44,492 SF
14th Floor Ste 1400	Medical Office	8,022 SF	Rate Upon Request
Full floor opportunity; available Fall 2024. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF
15th Floor Ste 1500	Medical Office	8,020 SF	Rate Upon Request
Full floor opportunity; available Fall 2024. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF
16th Floor Ste 1600	Medical Office	8,020 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Medical Space Type: Relet In Contiguous block: 44,492 SF
17th Floor Ste 1700	Medical Office	3,340 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: To Be Determined Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF
17th Floor Ste 1730	Medical Office	2,877 SF	Rate Upon Request
Date available: Now Lease term: 1 - 10 Years Service type: To Be Determined Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF
17th Floor Ste 1750	Medical Office	2,031 SF	Rate Upon Request
Spacious office/Medical suite with 2,095 sqft available. Date available: Now Lease term: 1 - 10 Years Service type: Triple Net Built out as: Standard Office Space Type: Relet In Contiguous block: 44,492 SF

Description

River Oaks Medical Tower is a 17-story, approximately 140,000-square-foot medical office building offering a contemporary approach to care in one of Houston’s most prestigious and well-connected neighborhoods. Positioned at the intersection of affluence, accessibility, and healthcare demand, the property has been thoughtfully reimagined to support the evolving needs of modern medical practices and their patients. 

Driven by Altera’s vision for redevelopment, the building features a reimagined first-floor lobby, refreshed elevator banks, an enhanced patient arrival experience, and a new rear entryway complemented by an onsite pocket park. These improvements prioritize seamless access, patient comfort, and an elevated sense of arrival while reinforcing the building’s position as a premier medical destination. The property offers unmatched visibility and immediate connectivity to Houston’s key inner-loop neighborhoods, including River Oaks, West University, Bellaire, Uptown, Midtown, Downtown, the Galleria, Rice Village, the Heights, and the Texas Medical Center—all within a short drive. This central location enables providers to draw from a broad and highly desirable patient base while maintaining convenience for physicians and staff. 

Within a three-mile radius, River Oaks Medical Tower benefits from a dense and affluent demographic profile, including a high daytime population, strong healthcare utilization, and a predominately privately insured patient mix. These fundamentals support long-term practice sustainability and make the building particularly attractive to specialty, outpatient, and boutique healthcare providers seeking proximity to demand rather than hospital campuses. 

To further enhance the tenant experience, the building offers move-in-ready spec suites ranging from approximately 2,500 to 3,000 square feet provide turnkey solutions for practices seeking immediate occupancy without construction delays. 

River Oaks Medical Tower stands as a differentiated medical office environment where care and wellness converge, combining location, design, and demographics to serve the next generation of healthcare delivery.

                
                    Highlights
                
                                Unparalleled visibility and exposure with panoramic perspectives from the freeway and surrounding areas.
                            
                                Ideal location for any medical user with easy access to the Southwest Freeway, Loop 610, The Galleria, Downtown, and Texas Medical Center. 
                            
                                Adjacent to the River Oaks Medical Center, Twelve Oaks Hospital, and a six-minute drive to Memorial Hermann Hospital and Houston Methodist Hospital.
                            
                                Direct access to affluent patient populations residing in proximity, including West University, Afton Oaks, River Oaks, and Tanglewood.
                            
                                Physicians in the building range from physical therapists and cosmetic surgeons to outpatient surgical experts and general medical practitioners.