344-346 E 110th St
New York, NY 10029 East Harlem

Located at 344 East 110th Street in East Harlem, this approximately 3,000 SF lower-level medical/commercial space offers a rare opportunity for medical users, adult daycare operators, and community facility businesses seeking a functional, accessible, and strategically located space in one of Manhattan’s fastest-evolving neighborhoods. The space is ADA compliant, features two bathrooms, central AC and heating, elevator access, and can be delivered turnkey or built to suit a tenant’s operational needs. The property also includes a modified elevator/lift system, making accessibility for patients, clients, staff, and visitors seamless. 
Positioned on the eastern side of East Harlem near 1st Avenue, the property benefits from a strong surrounding residential population, creating a built-in client base for medical, wellness, or community-oriented uses. The building itself is professionally maintained with on-site support and residences above, helping create consistent daily activity within the property. The block is quiet while still being conveniently located near neighborhood amenities including delis, retail businesses, and nearby self-storage facilities.
Transportation and regional connectivity are major highlights of this location. The property offers quick access to the Willis Avenue Bridge, Madison Avenue Bridge, FDR Drive, and I-87, allowing efficient travel throughout Manhattan, the Bronx, Westchester, and beyond. Employees and visitors can easily access the space via nearby subway lines at 110th Street, while Metro-North service at 125th Street is only a short commute away. The location also benefits from proximity to the RFK Bridge, providing convenient access to Queens and other boroughs. East Harlem has continued to experience significant residential and commercial development in recent years, with the future Second Avenue Subway expansion expected to further improve accessibility and long-term neighborhood growth.
Constructed in 2016, the property presents a first-time occupancy opportunity within a modern residential building. The combination of accessibility, infrastructure, residential density, and strong transportation access makes this an ideal opportunity for healthcare providers, adult daycare operators, therapy practices, nonprofit/community facility users, or other professional operators seeking a well-located Manhattan space.