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335-345 S Main St
Ann Arbor, MI 48104 Downtown Ann Arbor

$475 USD/MO

Storefront Retail Office For Lease  •  180 SF

Property Details

  • Property Type Storefront Retail Office
  • Year Built 1905
  • Total Building Size 17,729 SF
  • Tenancy Multiple
  • Building Class C
  • Zoning C2A
80 Transit Score
100 Walk Score

1 Space Available

Name Space Use Size Rent Details
2nd Floor Ste 205 Office 180 SF $31.66 USD/SF/YR 
This spacious single-room, second floor office space is available now for a reasonable $475!

The office is located in the heart of downtown Ann Arbor, in the beautifully maintained building at 343 South Main Street. The space has plenty of natural light from its window. All utilities are also included.

343 S Main also has a 24/7 keyless entry system and intercom/door release for easy and secure after-hour entry. The men's/women's common hallway bathrooms are located on the second floor. A 7-story parking structure conveniently located right behind the building. Call or text our office today, at (734)-761-6170 or email for an appointment.

We look forward to showing you the space soon!

  • Date available: Aug 2026
  • Lease term: 1 Years
  • Service type: Full Service Gross
  • Built out as: Standard Office
  • Space Type: Relet

Description 

Located in the heart of Ann Arbor’s vibrant downtown, 335-345 S Main Street, also known as the Curtis Building, offers premier retail and office opportunities with exceptional visibility along Main Street’s bustling corridor. The property benefits from an energetic mix of national and local tenants, surrounded by celebrated dining destinations, specialty boutiques, and cultural venues that attract year-round pedestrian activity. The site’s prominence ensures ample branding opportunities for retailers and professional spaces alike

Highlights

Highly visible storefront location on Ann Arbor’s active Main Street corridor.
Walkable destination surrounded by restaurants, entertainment, and residential developments.
Dynamic positioning near University of Michigan and central business district infrastructure.

Major Tenants

Tenant SF Occupied Lease End Date
Center for Collaborative Inquiry LLC 787 SF
Curtis Commercial LLC 787 SF
Keystone Media 787 SF
Michael Joseph Therapy 500 SF
Real Seafood Co 5,636 SF

Public Transportation

AirportDriveWalkDistance
Detroit Metro Wayne County 40 min - 28.1 mi
David Curtis 734-761-6170 Curtis Commercial
David Curtis 734-761-6170 Curtis Commercial