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275 Second Ave
Waltham, MA 02451 West End Waltham

Rate Upon Request

Office For Lease  •  10,150 SF

Property Details

  • Property Type Office
  • Year Built 2000
  • Total Building Size 106,654 SF
  • Tenancy Multiple
  • Building Class A
  • Zoning C
30 Transit Score
50 Walk Score

1 Space Available

Name Space Use Size Rent Details
3rd Floor Ste Office 10,150 SF Rate Upon Request
This 10,150 SF third-floor lab and office opportunity delivers a highly functional, turnkey environment designed to support a wide range of research and innovation uses.
The space features a flexible layout with multiple lab areas, and existing infrastructure including compressed air and vacuum systems. Tenants benefit from robust building systems, including emergency backup power, ensuring operational continuity for critical functions.
Beyond the lab, the building offers a best-in-class amenity package to support employee productivity and well-being. On-site features include a café serving breakfast and lunch, a fully equipped fitness center with locker rooms and towel service, and outdoor seating areas for collaboration or relaxation. An attached covered parking garage and additional surface parking provide convenience, while access to “The Grid” shuttle offers seamless connectivity to Alewife and surrounding areas.
Located within a dynamic neighborhood cluster, 275 Second Avenue provides immediate access to Waltham’s thriving biotech and technology community, along with nearby retail and dining option

  • Date available: Now
  • Lease term: Negotiable
  • Service type: Triple Net
  • Built out as: Standard Office
  • Space Type: Relet

Description

The Property has exceptional physical characteristics that are uniquely suited for life science. The building is situated in a transformed location 
with a wealth of amenities including the adjacent hotel, and numerous restaurants and 
entertainment venues. With an impressive tenant base and bordered by the world’s leading lab companies, the 
Property is in a unique position to capture the strong life science demand in Greater Boston.

LAB & SUITE DETAILS:
• Histology Lab with 6' chemical fume hood (CFH)
• Tissue Culture (TC) Lab
• Engineering Lab with dual anteroom access
• Two (2) Laser Labs
• Four (4) private offices plus CEO suite
• Open office area, shared office, and huddle room
• Conference room, reception, and
break room with pantry
• Dedicated server room
• Shipping/receiving with freight elevator access

Property Flyers

Amenities

  • Bio-Tech/ Lab Space
  • Bus Line
  • Controlled Access
  • Fitness Center
  • Food Service
  • Metro/Subway
  • Restaurant
  • Security System
  • Signage
  • Storage Space
  • Outdoor Seating
  • Air Conditioning

Major Tenants

Tenant SF Occupied Lease End Date
Alloy Therapeutics, Inc 2/29/2032
Blossom Innovations 5/31/2026
Violin Systems
Visterra 12/31/2029

Public Transportation

Commuter RailDriveWalkDistance
Kendal Green (Fitchburg/South Acton Line - Massachusetts Bay Transportation Authority Commuter Rail (Purple Line)) 4 min - 1.8 mi
6 min - 2.7 mi
AirportDriveWalkDistance
General Edward Lawrence Logan International 30 min - 16.4 mi
Worcester Regional 60 min - 41.2 mi

Parking Details

Parking Available: Yes
Reserved: No
Spaces Provided: 100
Type: Surface
Included in Rent: Yes
Jason Rexinis 617-869-1227 Colliers
Jason Rexinis 617-869-1227 Colliers