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2480 Mission St
San Francisco, CA 94110 Mission

Rate Upon Request

Medical For Lease • 445+ SF

Property Details

Property Type Medical
Year Built 1972
Total Building Size 36,969 SF
Tenancy Multiple
Building Class B
Zoning NC-3, San Francisco

89 Transit Score

99 Walk Score

13 Spaces Available

Name	Space Use	Size	Rent
1st Floor Ste 103	Medical Office	2,260 SF	Rate Upon Request
Street level office, with access to the street and to the lobby inside the building. Conveniently accessible and could fit all sorts of businesses, including startups, professional, medical,spa, physical therapy, financial, etc. Date available: May 2026 Lease term: Negotiable Service type: Triple Net Space Type: Relet
1st Floor Ste 104	Medical Office	975 SF	Rate Upon Request
Professional office suite suited for small practices or administrative use. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Office Space Type: Relet
1st Floor Ste 106	Medical Office	992 SF	Rate Upon Request
Plumbed dental layout featuring two operatory rooms designed for clinical workflow. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Office Space Type: Relet
1st Floor Ste 107 A	Medical Office	727 SF	Rate Upon Request
Efficient office suite suitable for solo practitioners or small teams. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Office Space Type: Relet
1st Floor Ste 107 B	Medical Office	445 SF	Rate Upon Request
Compact professional office ideal for therapy, counseling, or private practice use. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Office Space Type: Relet
2nd Floor Ste 212	Medical Office	2,854 SF	Rate Upon Request
Large upper-floor office offering flexibility for team-based workspace needs. Date available: Now Lease term: Negotiable Service type: Triple Net Built out as: Standard Office Space Type: Relet
2nd Floor Ste 214	Medical Office	1,109 SF	Rate Upon Request
1,109 square foot office/medical space along with a mix of private offices available. Second-floor dental layout with two plumbed operatories. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Medical Space Type: Relet
2nd Floor Ste 216	Medical Office	1,129 SF	Rate Upon Request
1,129 square foot office/medical space along with a mix of private offices available. Versatile office suite with efficient workspace configuration. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Medical Space Type: Relet
2nd Floor Ste 217	Medical Office	1,009 SF	Rate Upon Request
1,009 square foot office/medical space along with a mix of private offices available. Private office space positioned for professional services or wellness practices. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Dental Space Type: Relet
2nd Floor Ste 218-219	Medical Office	2,548 SF	Rate Upon Request
2,548 square foot office/medical space along with a mix of private offices available. Combined second-floor dental suite featuring four fully plumbed operatories. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Dental Space Type: Relet
2nd Floor Ste 220	Medical Office	1,176 SF	Rate Upon Request
1,176 square foot office/medical space along with a mix of private offices available. Bright and functional office suitable for a growing professional practice. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Dental Space Type: Relet
2nd Floor Ste 221	Medical Office	918 SF	Rate Upon Request
918 square foot office/medical space along with a mix of private offices available. Well-configured professional suite for clinical or general office users. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Dental Space Type: Relet
2nd Floor Ste 222	Medical Office	926 SF	Rate Upon Request
Efficient office layout for private practitioners or small teams. Date available: Now Lease term: Negotiable Service type: To Be Determined Built out as: Standard Office Space Type: Relet

Description

Located in San Francisco’s vibrant Mission District, 2480 Mission Street serves as a premier destination for medical, dental, wellness, and professional office users seeking a central, well-managed environment. The building offers a wide spectrum of suites, many of which are already configured for healthcare providers with plumbed operatories ready for immediate use. With flexible suite sizes and the option to combine spaces, tenants can scale operations as their practice grows. The property is positioned steps from BART and MUNI, providing seamless transit access across the Bay Area, and is surrounded by some of the Mission’s most beloved restaurants, cafés, and cultural institutions, creating an energetic and walkable atmosphere for both clients and staff. On-site parking with secure garage access via San Carlos Street further enhances convenience, while an attentive building management team ensures day-to-day operational support. The building maintains a professional environment tailored to medical providers, therapy practices, startups, and service-oriented businesses, offering a modern lobby, flexible configurations, and a community of complementary tenants. With its central location, excellent transit connectivity, and strong roster of professional and medical occupants, 2480 Mission Street stands as an exceptional opportunity for tenants seeking a well-positioned and highly serviceable office setting in one of the city’s most dynamic neighborhoods.

                
                    Highlights
                
                                Surrounded by top neighborhood amenities including popular restaurants, cafés, and cultural destinations.
                            
                                Prime Mission District location with immediate access to BART and MUNI for seamless regional connectivity.
                            
                                On-site secure parking garage offering added convenience for tenants and clients.
                            
                                Diverse mix of medical and professional tenants creating a synergistic environment for healthcare and service providers.

Property Flyers

2480 Mission Street Jan-16-2026

Amenities

24 Hour Access
Wheelchair Accessible
Roof Terrace

Public Transportation

Commuter Rail	Drive	Walk	Distance
	7 min	-	2.6 mi
	10 min	-	4.4 mi
Transit/Subway	Drive	Walk	Distance
24th St Mission Station (Dublin/Pleasanton - Millbrae - Bay Area Rapid Transit (BART), Fremont - Daly City - Bay Area Rapid Transit (BART), Pittsburg/Bay Point - San Francisco International - Bay Area Rapid Transit (BART), Richmond - Millbrae - Bay Area Rapid Transit (BART))	3 min	8 min	0.4 mi
21st Street (J Church - San Francisco Municipal Railway (MUNI Metro))	3 min	9 min	0.4 mi
Liberty Street (J Church - San Francisco Municipal Railway (MUNI Metro))	3 min	9 min	0.5 mi
Church and 18th Street (J Church - San Francisco Municipal Railway (MUNI Metro))	2 min	14 min	0.7 mi
Airport	Drive	Walk	Distance
San Francisco International	22 min	-	12.5 mi
Metro Oakland International	34 min	-	21.1 mi
Norman Y Mineta San Jose International	58 min	-	44.1 mi

Parking Details

Parking Available:	Yes
Reserved:	No
Type:	SurfaceTandem
Included in Rent:	Yes

Manaf Darawshe 650-533-8036 Starboard Commercial Real Estate

2480 Mission St San Francisco, CA 94110 Mission