1250 Main St
Napa, CA 94559 Central Napa

Rate Upon Request

Medical For Lease • 200+ SF

Property Details

Property Type Medical
Year Built 2008
Total Building Size 45,455 SF
Tenancy Multiple
Building Class A
Zoning DMU

37 Transit Score

96 Walk Score

6 Spaces Available

Name	Space Use	Size	Rent
1st Floor Ste 1245 West Street	Retail	938 SF	Rate Upon Request
Napa Innovation Center, located at 1250 Main Street in downtown Napa, CA is a Class A office building offering approximately 50,000 square feet of professional space designed for modern business needs. With its striking architecture and prominent corner presence at Main and Clinton Streets, this three-story building delivers both visibility and prestige in one of Napa’s most walkable and dynamic commercial districts. Surrounded by top-tier restaurants, boutique retail, luxury hotels, and cultural destinations, the property boasts a Walk Score of 97—placing tenants at the center of it all. The building features a variety of fully built-out suites ranging from private offices to expansive, full-floor layouts, allowing businesses to scale and customize as needed. Inside, tenants are welcomed by elegant stone lobby flooring, high-end finishes, and abundant natural light through double-pane, tinted glass windows. Each floor is served by elevator access and includes well-appointed restrooms, creating a professional and comfortable environment for staff and guests alike. With modern energy management systems, high-speed data connectivity, and keyless after-hours access, Napa Innovation Center is built to meet the demands of today’s high-performance teams. Parking is available with 30 surface spaces offered at an affordable monthly rate—an invaluable asset in Napa’s bustling downtown. Beyond its physical features, the property offers a strategic advantage as part of Napa’s thriving business ecosystem. Known globally for its wine industry, culture, and culinary excellence, the region also supports a growing network of companies in technology, healthcare, design, and professional services. Its central location provides convenient access to major transportation routes and is within one hour of three international airports, offering seamless local and international connectivity. For companies seeking a prestigious address that balances form and function in one of Northern California’s most iconic destinations, Napa Innovation Center at 1250 Main Street delivers a rare and compelling opportunity to thrive in the heart of downtown Napa. Date available: Jan 2026 Lease term: Negotiable Service type: Triple Net Built out as: Professional Services Space Type: Relet
2nd Floor Ste 200	Office	200 SF	Rate Upon Request
Date available: Now Lease term: Negotiable Service type: Full Service Gross Space Type: Relet
3rd Floor Ste 300	Office	13,085 SF	Rate Upon Request
Date available: Now Lease term: Negotiable Service type: To Be Determined Space Type: Relet
3rd Floor Ste 300A	Office	7,113 SF	Rate Upon Request
Date available: Now Lease term: Negotiable Service type: To Be Determined Space Type: Relet
3rd Floor Ste 325A	Office	3,223 SF	Rate Upon Request
Date available: Now Lease term: Negotiable Service type: To Be Determined Space Type: Relet
3rd Floor Ste 350A	Office	3,476 SF	Rate Upon Request
Date available: Now Lease term: Negotiable Service type: To Be Determined Space Type: Relet

Description

Napa Innovation Center, located at 1250 Main Street in downtown Napa, CA is a Class A office building offering approximately 50,000 square feet of professional space designed for modern business needs. With its striking architecture and prominent corner presence at Main and Clinton Streets, this three-story building delivers both visibility and prestige in one of Napa’s most walkable and dynamic commercial districts. Surrounded by top-tier restaurants, boutique retail, luxury hotels, and cultural destinations, the property boasts a Walk Score of 97—placing tenants at the center of it all.
The building features a variety of fully built-out suites ranging from private offices to expansive, full-floor layouts, allowing businesses to scale and customize as needed. Inside, tenants are welcomed by elegant stone lobby flooring, high-end finishes, and abundant natural light through double-pane, tinted glass windows. Each floor is served by elevator access and includes well-appointed restrooms, creating a professional and comfortable environment for staff and guests alike. With modern energy management systems, high-speed data connectivity, and keyless after-hours access, Napa Innovation Center is built to meet the demands of today’s high-performance teams.
Parking is available with 30 surface spaces offered at an affordable monthly rate—an invaluable asset in Napa’s bustling downtown. Beyond its physical features, the property offers a strategic advantage as part of Napa’s thriving business ecosystem. Known globally for its wine industry, culture, and culinary excellence, the region also supports a growing network of companies in technology, healthcare, design, and professional services. Its central location provides convenient access to major transportation routes and is within one hour of three international airports, offering seamless local and international connectivity.
For companies seeking a prestigious address that balances form and function in one of Northern California’s most iconic destinations, Napa Innovation Center at 1250 Main Street delivers a rare and compelling opportunity to thrive in the heart of downtown Napa.

                
                    Highlights
                
                                Class A Building in Napa, Wine & Culinary Capital of the World
                            
                                Ideal Location for AgTech, MedTech, CleanTech & Professional Service Businesses
                            
                                Global Wine Production Hub, Leveraging Regional Prestige
                            
                                High Visibility & Thriving Local Economy for Strategic Growth
                            
                                Access to Skilled Workforce in Hospitality, Wine, Food, and Tech
                            
                                2,500 to 14,000 sq ft of office and medical space in Napa Innovation Center